EDUFLUVAC workshop on experimental animal models for universal influenza vaccines

The second EDUFLUVAC workshop on experimental animal models for universal influenza vaccines took place on 23-24 June 2016 at the Biomedical Primate Research Centre, Rijswijk, The Netherlands.  This workshop was organised by EDUFLUVAC, EU - Framework program 7 funded project with the financial support of Sanofi Pasteur and Viroclinics.

Influenza experts from academia, industry, European and American regulatory authorities and other key stakeholders met to initiate discussions on how the influenza vaccine community should address the choice of animal models for preclinical evaluation of universal influenza vaccines.  The program included a diversity of influenza models from well established, publicly accepted as “gold standards” to cutting edge newly developed animal models as well as ex-vivo approaches and human model.  Following lively discussions the audience concluded that different vaccine approaches require evaluation in different animal models and there is a certain need for more collaboration in the field.  The key for success was identified as: communication, communication, communication!

Workshop participants

The EDUFLUVAC organising committee warmly thanks all participants of the workshop for their attendance and valuable contribution and the sponsors for the kind support.

Scientific Organising Committee members:
Ed Remarque (BPRC), Gerrit Koopman (BPRC), Norbert Stockhofe (CVI), Othmar Engelhardt (NIBSC), Sophie Houard (EVI), Eric Nebie (EVI), Sophia Hundt (EVI).

Funding:

 

 

 

Supported by:

Agenda and list of participants

Presentations:

Introduction to the workshop / Summary of the 1st EDUFLUVAC Workshop on immunoassay standardisation for universal flu vaccines / Othmar Engelhardt

Session 1: Ferret model

1. Ferret model - introduction / Stacey Schultz-Cherry

2. Ferret model – vaccine evaluation / Judith van den Brand

3. Immunocompromised influenza ferret model for studying safety, efficacy and resistance / Koert Stittelaar

4. Ferret model in the COBRA approach / Ted Ross

Session 2: Non-human primate model 

1. Non-human primate model – introduction and vaccine evaluation / Petra Mooij

2. Aerosol and intra-nasal challenge routes in non-human primates and ferrets / Anthony Marriott

Session 3: Rodent models

1. Mouse model - challenge studies / Harmjan Kuipers

2. Humanised mouse model - vaccine evaluation / Carlos Guzmán

3. Guinea pig transmission model – introduction and vaccine evaluation / Nicole Bouvier

4. Cotton rat model / Anke Huckriede

Session 4: Swine model 

1. Swine model - introduction / Daniela Rajao

2. Harnessing local respiratory immunity in protection against influenza in pigs / Elma Tchilian

Session 5: Comparable overview of various animal models

1. Host response to influenza virus infection and systems biology: pig, primate, ferret, and mouse model / Michael G. Katze

2. Evaluation of broadly protective vaccines in different animal and ex-vivo models / Harold Kleanthous

3. Ex-vivo approach for studying influenza / Wendy Barclay

4. Human model versus animal model / Nicolas Noulin

Session 6: Regulatory view on animal models

1. Harmonisation and standardisation of the animal models – what is feasible? / Harmjan Kuipers

2. Regulatory view on experimental animal models in influenza vaccine research – A European regulator’s point of view / Jan Willem van der Laan

3. Regulatory view on experimental animal models in influenza vaccine research – Center for Biologics Evaluation and Research perspective / Hana Golding