Biomedical Primate Research Centre (BPRC), The Netherlands

The Biomedical Primate Research Centre (BPRC) is a not for profit research foundation with a strong background in vaccine development.  BPRC investigators have pioneered key steps in the development of malaria, HIV, Hepatitis C, West Nile virus and TB vaccine candidates.  The non-human primate facilities at BPRC allow challenge studies with pathogens up to BSL3plus level.  BPRC offers state of the art immunological expertise and animal facilities (Association for Assessment and Accreditation of Laboratory Animal Care International - AAALAC - accredited) and is fully compliant with regulations on the use of non-human primates for medical research.

BPRC investigators have long standing expertise in the development of malaria, HIV, Hepatitis C, tuberculosis and influenza vaccine candidates and are the inventors of the multivalent AMA1-DiCo antigens, currently in clinical development.  Key points in the vaccine evaluation are monitoring of mucosal and systemic immune responses and safety evaluation, including a full spectrum of haematology and clinical chemistry parameters and full histopathology.

BPRC will be work package leader of work package (WP) 4 (Challenge studies).  BPRC will also participate in WP 2 (Antigen selection and production) and WP 3 (Mouse immunogenicity studies).